Chinifur

• CAT Number: I024544
• CAS Number: 70762-66-2
• Molecular Formula: C25H30N4O4
• Molecular Weight: 450.54
• Purity: 98%
• Synonyms: Chinifur
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: 4-Quinolinecarboxamide, N-(4-(diethylamino)-1-methylbutyl)-2-(2-(5-nitro-2-furanyl)ethenyl)-
• InChI: InChI=1S/C25H30N4O4/c1-4-28(5-2)16-8-9-18(3)26-25(30)22-17-19(27-23-11-7-6-10-21(22)23)12-13-20-14-15-24(33-20)29(31)32/h6-7,10-15,17-18H,4-5,8-9,16H2,1-3H3,(H,26,30)/b13-12+
• InChIKey: MTHCJDYSIZMKAC-OUKQBFOZSA-N
• SMILES: O=C(C1=CC(/C=C/C2=CC=C([N+]([O-])=O)O2)=NC3=CC=CC=C13)NC(C)CCCN(CC)CC

Chinifur（Cat No.:I024544） is a selective inhibitor and “subversive substrate” for Trypanosoma congolense trypanothione reductase, an enzyme involved in the redox balance of the parasite. By acting as a subversive substrate, Chinifur disrupts the normal functioning of trypanothione reductase, impairing the parasite’s ability to maintain its redox state.

Reference

1: Cenas N, Bironaite D, Dickancaite E, Anusevicius Z, Sarlauskas J, Blanchard JS. Chinifur, a selective inhibitor and “subversive substrate” for Trypanosoma congolense trypanothione reductase. Biochem Biophys Res Commun. 1994 Oct 14;204(1):224-9. doi: 10.1006/bbrc.1994.2448. PMID: 7945363.