Chinoin 127

• CAT Number: I024547
• CAS Number: 54606-29-0
• Molecular Formula: C11H17N3O2
• Molecular Weight: 223.28
• Purity: 98%
• Synonyms: Chinoin 127; CH127; CH-127; CH 127
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, 1,6,7,8,9,9a-hexahydro-1,6-dimethyl-4-oxo-
• InChI: InChI=1S/C11H17N3O2/c1-7-4-3-5-9-13(2)6-8(10(12)15)11(16)14(7)9/h6-7,9H,3-5H2,1-2H3,(H2,12,15)
• InChIKey: PDYZVPFJLHCRGG-UHFFFAOYSA-N
• SMILES: O=C(C1=CN(C)C(CCCC2C)N2C1=O)N

Chinoin 127 (Cat No.: I024547) is a synthetic histamine H2 receptor antagonist that inhibits gastric acid secretion, making it useful in the treatment of peptic ulcers and gastroesophageal reflux disease (GERD). By selectively blocking H2 receptors in the stomach lining, it reduces acid production without significantly affecting other histamine pathways. Chinoin 127 exhibits good oral bioavailability, potency, and a favorable safety profile. It serves as a valuable compound for studying gastric acid regulation and developing therapies for acid-related gastrointestinal conditions.

Reference

1: Kalmár L, Láng I, Gonzelez-Cabello P, Gergely P, Fehér J. Effects on immune reactions of non-steroidal anti-inflammatory drugs and of two new pyrido- pyrimidine derivatives (CHINOIN 127 and CHINOIN 105). Acta Med Hung. 1986;43(3):255-63. PMID: 3295745.
2: Bernus I, Tóth A, Kálóy K, Takácsy TE. Analytical studies on the hydrolysis of Chinoin-102 and Chinoin-127, candidate compounds for stability studies. J Pharm Biomed Anal. 1985;3(5):405-15. doi: 10.1016/0731-7085(85)80054-6. PMID: 16867652.
3: Kapui Z, Boér K, Hermecz I, Gyíres K. The mechanism of cytoprotective effect of CHINOIN-127. Acta Physiol Hung. 1992;80(1-4):237-45. PMID: 1345193.
4: Gergelyné-Zobin A, Szász G, Hermecz I. Pirido-pirimidin-karboxamid (CHINOIN-127) dehidrogénezödéssel járó bomlásáról [Dehydrogenation accompanied decomposition of pyrido-pyrimidine carboxamide (CHINOIN-127)]. Acta Pharm Hung. 1983 Sep;53(5):222-8. Hungarian. PMID: 6605660.
5: Kovács Z, Kapui Z, Cser I, Hermecz I, Rózsa I, Blaskó G. The gastroprotective effect of CHINOIN-127 on indomethacin induced gastric ulcer in rats. Acta Physiol Hung. 1990;75 Suppl:185-6. PMID: 2115229.
6: Knoll J, Gyires K, Mészáros Z. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido [1,2-a] pyrimidine-3-carboxamide (Chinoin-127), a potent non-narcotic analgesic and antiinflammatory agent. Arzneimittelforschung. 1979;29(5):766-73. PMID: 315232.
7: Knoll J, Gyires K, Hermecz I. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks’ daily administration of indomethacin. Drugs Exp Clin Res. 1987;13(5):253-8. PMID: 3500028.
8: Rózsa I, Kapui Z, Szécsi T, Hermecz I, Blaskó G. Synthesis of prostacyclin and thromboxane A2 by rat gastric mucosa. Comparison of 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido (1,1-a)-pyrimidine-3-carboxamide and cimetidine. Arzneimittelforschung. 1989 Jun;39(6):686-9. PMID: 2673252.