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54606-29-0-Chinoin 127 Chinoin 127

Chinoin 127

For research use only. Not for therapeutic Use.

  • CAT Number: I024547
  • CAS Number: 54606-29-0
  • Molecular Formula: C11H17N3O2
  • Molecular Weight: 223.28
  • Purity: 98%
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Related Small Molecules: Eclalbasaponin I     ML148     3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N,12,16,20,24-heptamethyl-10-oxo-7-[(3,7,11,15-tetramethyl-1-oxohexadecyl)oxy]-, inner salt, 4-oxide, (7R)-    

Chinoin 127 is a biochemical


Catalog Number I024547
CAS Number 54606-29-0
Synonyms

Chinoin 127; CH127; CH-127; CH 127

Molecular Formula C11H17N3O2
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, 1,6,7,8,9,9a-hexahydro-1,6-dimethyl-4-oxo-
InChI InChI=1S/C11H17N3O2/c1-7-4-3-5-9-13(2)6-8(10(12)15)11(16)14(7)9/h6-7,9H,3-5H2,1-2H3,(H2,12,15)
InChIKey PDYZVPFJLHCRGG-UHFFFAOYSA-N
SMILES O=C(C1=CN(C)C(CCCC2C)N2C1=O)N
Reference

1: Kalmár L, Láng I, Gonzelez-Cabello P, Gergely P, Fehér J. Effects on immune reactions of non-steroidal anti-inflammatory drugs and of two new pyrido- pyrimidine derivatives (CHINOIN 127 and CHINOIN 105). Acta Med Hung. 1986;43(3):255-63. PMID: 3295745.
2: Bernus I, Tóth A, Kálóy K, Takácsy TE. Analytical studies on the hydrolysis of Chinoin-102 and Chinoin-127, candidate compounds for stability studies. J Pharm Biomed Anal. 1985;3(5):405-15. doi: 10.1016/0731-7085(85)80054-6. PMID: 16867652.
3: Kapui Z, Boér K, Hermecz I, Gyíres K. The mechanism of cytoprotective effect of CHINOIN-127. Acta Physiol Hung. 1992;80(1-4):237-45. PMID: 1345193.
4: Gergelyné-Zobin A, Szász G, Hermecz I. Pirido-pirimidin-karboxamid (CHINOIN-127) dehidrogénezödéssel járó bomlásáról [Dehydrogenation accompanied decomposition of pyrido-pyrimidine carboxamide (CHINOIN-127)]. Acta Pharm Hung. 1983 Sep;53(5):222-8. Hungarian. PMID: 6605660.
5: Kovács Z, Kapui Z, Cser I, Hermecz I, Rózsa I, Blaskó G. The gastroprotective effect of CHINOIN-127 on indomethacin induced gastric ulcer in rats. Acta Physiol Hung. 1990;75 Suppl:185-6. PMID: 2115229.
6: Knoll J, Gyires K, Mészáros Z. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido [1,2-a] pyrimidine-3-carboxamide (Chinoin-127), a potent non-narcotic analgesic and antiinflammatory agent. Arzneimittelforschung. 1979;29(5):766-73. PMID: 315232.
7: Knoll J, Gyires K, Hermecz I. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks’ daily administration of indomethacin. Drugs Exp Clin Res. 1987;13(5):253-8. PMID: 3500028.
8: Rózsa I, Kapui Z, Szécsi T, Hermecz I, Blaskó G. Synthesis of prostacyclin and thromboxane A2 by rat gastric mucosa. Comparison of 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido (1,1-a)-pyrimidine-3-carboxamide and cimetidine. Arzneimittelforschung. 1989 Jun;39(6):686-9. PMID: 2673252.

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