For research use only, not for therapeutic use.
CHIR-124（Cat No.:I003475）is a selective inhibitor of glycogen synthase kinase 3 (GSK-3), an enzyme involved in various cellular processes, including cell survival, proliferation, and metabolism. By inhibiting GSK-3, CHIR-124 can enhance Wnt signaling pathways and promote neurogenesis, making it a candidate for neuroprotective and regenerative therapies. It has shown potential in preclinical studies for conditions such as Alzheimer’s disease and cancer, where GSK-3 dysregulation is implicated. Ongoing research focuses on its therapeutic applications and the exploration of optimal dosing strategies to maximize efficacy while minimizing side effects.
| Catalog Number | I003475 |
| CAS Number | 405168-58-3 |
| Synonyms | 4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-6-chloro-3-(1,3-dihydrobenzimidazol-2-ylidene)quinolin-2-one |
| Molecular Formula | C23H22ClN5O |
| Purity | ≥95% |
| Target | Chk |
| Solubility | DMSO: ≥ 14 mg/mL |
| Storage | 3 years -20℃ powder |
| IUPAC Name | 4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one |
| InChI | InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m1/s1 |
| InChIKey | MOVBBVMDHIRCTG-LJQANCHMSA-N |
| SMILES | C1CN2CCC1[C@@H](C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5 |
| Reference | </br>1:Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints. Tao Y, Leteur C, Yang C, Zhang P, Castedo M, Pierré A, Golsteyn RM, Bourhis J, Kroemer G, Deutsch E.Cell Cycle. 2009 Apr 15;8(8):1196-205. Epub 2009 Apr 16. PMID: 19305158 </br>2:CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Tse AN, Rendahl KG, Sheikh T, Cheema H, Aardalen K, Embry M, Ma S, Moler EJ, Ni ZJ, Lopes de Menezes DE, Hibner B, Gesner TG, Schwartz GK.Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):591-602. PMID: 17255282 Free Article |
