For research use only. Not for therapeutic Use.
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM[1].
Chlorahololide C (0.1-100 μM) inhibits the delayed rectifier K+ current (IK) in rat dissociated hippocampal neurons, with an IC50 of 3.6 μM[1].
| Catalog Number | R066104 |
| CAS Number | 1007859-25-7 |
| Synonyms | methyl 2-[(2S,7R,8S,10S,12R,13S,14S,16S,17S,19R,20S,21R)-7-acetyloxy-16,21-dihydroxy-5,13,20-trimethyl-9-methylidene-4,22-dioxo-3-oxaoctacyclo[14.7.1.02,6.02,14.08,13.010,12.017,19.020,24]tetracosa-1(24),5-dien-23-ylidene]propanoate |
| Molecular Formula | C33H36O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C33H36O9/c1-11-15-8-16(15)30(5)19-10-32(39)18-9-17(18)31(6)26(32)23(20(24(35)27(31)36)12(2)28(37)40-7)33(19)22(13(3)29(38)42-33)25(21(11)30)41-14(4)34/h15-19,21,25,27,36,39H,1,8-10H2,2-7H3/t15-,16-,17-,18+,19+,21-,25-,27+,30-,31+,32+,33-/m1/s1 |
| InChIKey | FUWHPWXSVUDXDS-NCZSDFTMSA-N |
| SMILES | CC1=C2C(C3C(=C)C4CC4C3(C5C2(C6=C7C(C8CC8C7(C5)O)(C(C(=O)C6=C(C)C(=O)OC)O)C)OC1=O)C)OC(=O)C |
| Reference | [1]. Yang SP, et, al. Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius. Tetrahedron. 2008 Feb; 64(9):2027-2034. |
