Chloramphenicol

• CAT Number: A001107
• CAS Number: 56-75-7
• Molecular Formula: C11H12Cl2N2O5
• Molecular Weight: 323.13
• Purity: 98%
• Synonyms: Chloromycetin
• Target: Metabolic Enzyme/Protease
• Solubility: >16.2mg/mL in DMSO
• Appearance: White solid
• Storage: 3 years -20C powder
• Analysis method: HPLC
• IUPAC Name: 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
• InChI: InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
• InChIKey: WIIZWVCIJKGZOK-RKDXNWHRSA-N
• SMILES: C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

Chloramphenicol（Cat No.:A001107）is a high-purity broad-spectrum antibiotic widely used in microbiological and pharmaceutical research. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. Effective against both Gram-positive and Gram-negative bacteria, chloramphenicol is particularly valuable in studying antimicrobial mechanisms and resistance. It is also used as a reference standard in analytical testing and quality control. Despite its potent activity, chloramphenicol’s use is limited in clinical settings due to potential side effects, making it a crucial tool for advancing antimicrobial research and drug development.

Overview of Clinical Research

Chloramphenicol is a protein synthesis inhibitor that is used to treat bacterial infection.

Reference

1.Sharma K.K., Bhatnagar-Mathur P. and Thorpe T.A. Genetic transformation technology: status and problems. In Vitro Cell. Dev. Biol.—Plant 41:102–112, March–April 2005

2.Li W., Ruf S. and Bock R., Chloramphenicol acetyltransferase as selectable marker for plastid transformation. Plant Mol Biol (2011) 76:443–451

3.Mayer, Gene, Dr. /Antibiotics – Protein Synthesis, Nucleic Acid Synthesis, and Metabolism./ University of South Carolina School of Medicine. Web. 21 Aug. 2012.