Chloramphenicol

• CAT Number: A001107
• CAS Number: 56-75-7
• Molecular Formula: C11H12Cl2N2O5
• Molecular Weight: 323.13
• Purity: 98%
• Synonyms: Chloromycetin
• Target: Antibiotic
• Solubility: >16.2mg/mL in DMSO
• Appearance: White solid
• Storage: 3 years -20C powder
• Analysis method: HPLC
• IUPAC Name: 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
• InChI: InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
• InChIKey: WIIZWVCIJKGZOK-RKDXNWHRSA-N
• SMILES: C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

Chloramphenicol (CAS 56-75-7) is a bacteriostatic antibiotic that inhibits bacterial protein synthesis.
After entering a bacterial cell, chloramphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to chloramphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.

Overview of Clinical Research

Chloramphenicol is a protein synthesis inhibitor that is used to treat bacterial infection.

Reference

1.Sharma K.K., Bhatnagar-Mathur P. and Thorpe T.A. Genetic transformation technology: status and problems. In Vitro Cell. Dev. Biol.—Plant 41:102–112, March–April 2005

2.Li W., Ruf S. and Bock R., Chloramphenicol acetyltransferase as selectable marker for plastid transformation. Plant Mol Biol (2011) 76:443–451

3.Mayer, Gene, Dr. /Antibiotics – Protein Synthesis, Nucleic Acid Synthesis, and Metabolism./ University of South Carolina School of Medicine. Web. 21 Aug. 2012.