Chloramphenicol Palmitate

• CAT Number: R023220
• CAS Number: 530-43-8
• Molecular Formula: C27H42Cl2N2O6
• Molecular Weight: 561.54
• Purity: ≥95%
• Synonyms: (2R,3R)-2-[(Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl Ester Hexadecanoic Acid; [R-(R*,R*)]-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl Ester Hexadecanoic Acid; Palmitic acid Ester with Chloramphenicol; Palmitic Acid α-e
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: [(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate
• InChI: InChI=1S/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1
• InChIKey: PXKHGMGELZGJQE-ILBGXUMGSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@H]([C@@H](C1=CC=C(C=C1)[N+](=O)[O-])O)NC(=O)C(Cl)Cl

Chloramphenicol Palmitate（Cat No.:R023220）is an esterified prodrug form of chloramphenicol, designed to enhance its stability and palatability, especially for pediatric use. Once administered, it converts to active chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, leading to bacterial growth inhibition. Chloramphenicol Palmitate is effective against a wide range of gram-positive and gram-negative bacteria and is commonly used for serious infections like typhoid fever and meningitis. Its improved taste and stability make it suitable for oral suspensions in children.

Reference

The structure of chloramphenicol palmitate. Edgerton W.H. et al. J. Am. Chem. Soc. 1955, 77, 27.