Chloramphenicol Succinate Sodium

• CAT Number: R026315
• CAS Number: 982-57-0
• Molecular Formula: C15H15Cl2N2O8Na
• Molecular Weight: 445.20
• Purity: 99%
• Synonyms: 1-[(2R,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] Ester Butanedioic Acid Sodium Salt; Mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] Ester Butanedioic Acid Monosodium Salt; Betamicetin; Chloramphen
• Target: Bacterial
• Appearance: White solid
• Storage: Store at RT
• Analysis method: HPLC
• IUPAC Name: sodium;4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoate
• InChI: InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1
• InChIKey: RPLOPBHEZLFENN-HTMVYDOJSA-M
• SMILES: C1=CC(=CC=C1[C@H]([C@@H](COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]

Chloramphenicol Succinate Sodium（Cat No.:R026315）is a water-soluble prodrug of chloramphenicol, commonly used for the treatment of bacterial infections. Upon administration, it is rapidly converted to active chloramphenicol in the body. It has a broad-spectrum activity against both Gram-positive and Gram-negative bacteria. Chloramphenicol works by inhibiting bacterial protein synthesis, making it effective in treating infections such as meningitis, typhoid fever, and respiratory infections. The sodium succinate formulation enhances its solubility and bioavailability, improving its efficacy in intravenous applications. It is typically administered in hospital settings for severe infections.

Reference

Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Ambekar C.S. et al. Toxicology in Vitro 2004, 18, 441.