For research use only. Not for therapeutic Use.
Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine’s central actions in a potent, long-lasting and pharmacologically selective way[1].
Chlorisondamine (0.2, 1.0, 5.0 μg; IV; single dosage) antagonizes the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks[1].
| Catalog Number | I010352 |
| CAS Number | 96750-66-2 |
| Synonyms | trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-1,3-dihydroisoindol-2-ium-2-yl)ethyl]azanium;diiodide |
| Molecular Formula | C14H20Cl4I2N2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2 |
| InChIKey | FPNVAOZHQUJJJQ-UHFFFAOYSA-L |
| SMILES | C[N+]1(CC2=C(C1)C(=C(C(=C2Cl)Cl)Cl)Cl)CC[N+](C)(C)C.[I-].[I-] |
| Reference | [1]. Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83(2):527-535. doi:10.1111/j.1476-5381.1984.tb16517.x [2]. Clarke PB, et al. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994 Feb;111(2):397-405. [3]. Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83(2):527-535. doi:10.1111/j.1476-5381.1984.tb16517.x |
