Chlormadinone acetate

• CAT Number: I003055
• CAS Number: 302-22-7
• Molecular Formula: C23H29ClO4
• Molecular Weight: 404.93
• Purity: ≥95%
• Synonyms: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione; 17-Acetoxy-6-chloro-6-dehydroprogesterone; 6-Chloro-17-acetoxy-4,6-pregnadiene-3,20-dione; Chronosyn; Fertiletten
• Target: Estrogen/progestogen Receptor
• Solubility: DMSO: ≥ 4.5 mg/mL, Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Storage: -20°C Freezer
• InChI: 1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3/t16-,17+,18+,21-,22+,23+/m1/s1
• InChIKey: QMBJSIBWORFWQT-DFXBJWIESA-N
• SMILES: CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)CCC34C)Cl)C)OC(=O)C

Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.

Chlormadinone acetate (abbreviated as CMA) (INN, USAN, BAN, JAN) (sold under brand names including Clordion, Gestafortin, Lormin, Non-Ovlon, Normenon, Verton, and many others), and also known as 17α-acetoxy-6-chloro-6-dehydroprogesterone, is a steroidal progestin with additional antiandrogen and antigonadotropic (and by extension antiestrogenic) effects. CMA has been used in the treatment of vaginal bleeding, oligomenorrhea, polymenorrhea, hypermenorrhea, secondary amenorrhea, and endometriosis. It has also been used clinically as a hormonal contraceptive, and in part due to its capacity to lower estrogen levels, but also for improved effectiveness in contraception, chlormadinone has frequently been combined with ethinylestradiol for this purpose.

Reference

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effect of chlormadinone acetate on odontogenic differentiation of human dental
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2: Siegenthaler PF, Zhao Y, Zhang K, Fent K. Reproductive and transcriptional
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3: Grandi G, Napolitano A, Xholli A, Tirelli A, Di Carlo C, Cagnacci A. Effect of
oral contraceptives containing estradiol and nomegestrol acetate or
ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea. Gynecol
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4: Yildizhan R, Gokce AI, Yildizhan B, Cim N. Comparison of the effects of
chlormadinone acetate versus drospirenone containing oral contraceptives on
metabolic and hormonal parameters in women with PCOS for a period of two-year
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5: Kim JM, Lee JE, Ryu SH, Suh PG. Chlormadinone acetate promotes osteoblast
differentiation of human mesenchymal stem cells through the ERK signaling
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6: Gahr M, Freudenmann RW, Connemann BJ, Kölle MA, Schönfeldt-Lecuona C. Rapid
relapse in depression following initialization of oral contraception with ethinyl
estradiol and chlormadinone acetate. Gen Hosp Psychiatry. 2014
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7: Koike H, Morikawa Y, Matsui H, Shibata Y, Ito K, Suzuki K. Chlormadinone
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