For research use only. Not for therapeutic Use.
Chloro-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044713 |
| CAS Number | 1442085-43-9 |
| Synonyms | tert-butyl 2-[2-(2-chloroethoxy)ethoxy]acetate |
| Molecular Formula | C10H19ClO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H19ClO4/c1-10(2,3)15-9(12)8-14-7-6-13-5-4-11/h4-8H2,1-3H3 |
| InChIKey | SXFVGSLYPJXDFE-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)COCCOCCCl |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
