For research use only. Not for therapeutic Use.
Chlorogenic acid（Cat No.:I003163）is a polyphenolic compound widely found in coffee, fruits, and vegetables, known for its potent antioxidant, anti-inflammatory, and antidiabetic properties. By inhibiting glucose-6-phosphatase, chlorogenic acid helps reduce blood glucose levels, making it beneficial for type 2 diabetes management. It also supports weight loss by modulating fat metabolism and has shown protective effects on cardiovascular health. Due to its antioxidant capacity, chlorogenic acid aids in neutralizing free radicals, supporting cellular health. Its diverse biological activities make it a valuable compound in nutritional supplements and therapeutic research.
| Catalog Number | I003163 |
| CAS Number | 327-97-9 |
| Synonyms | 3-O-Caffeoylquinic acid;Heriguard;NSC 407296 |
| Molecular Formula | C16H18O9 |
| Purity | ≥95% |
| Solubility | DMSO: ≥ 32 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | (1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid |
| InChI | InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1 |
| InChIKey | CWVRJTMFETXNAD-JUHZACGLSA-N |
| SMILES | C1[C@H]([C@H]([C@@H](C[C@@]1(C(=O)O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O |
| Reference | </br>1:Enhanced solubility and antioxidant activity of chlorogenic acid-chitosan conjugates due to the conjugation of chitosan with chlorogenic acid. Rui L, Xie M, Hu B, Zhou L, Saeeduddin M, Zeng X.Carbohydr Polym. 2017 Aug 15;170:206-216. doi: 10.1016/j.carbpol.2017.04.076. Epub 2017 Apr 29. PMID: 28521988 </br>2:NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet. Amato A, Caldara GF, Nuzzo D, Baldassano S, Picone P, Rizzo M, Mulè F, Di Carlo M.Nutrients. 2017 May 13;9(5). pii: E492. doi: 10.3390/nu9050492. PMID: 28505074 Free Article</br>3:UHPLC-ESI-MS/MS determination and pharmacokinetics of pinoresinol glucoside and chlorogenic acid in rat plasma after oral administration of Eucommia ulmoides Oliv extract. Gong X, Luan Q, Zhou X, Zhao Y, Zhao C.Biomed Chromatogr. 2017 May 10. doi: 10.1002/bmc.4008. [Epub ahead of print] PMID: 28493441 </br>4:The Role of Chlorogenic Acid Supplementation in Anemia and Mineral Disturbances Induced by 4-Tert-Octylphenol Toxicity. Koriem KMM, Arbid MSS, Gomaa NE.J Diet Suppl. 2017 May 10:1-17. doi: 10.1080/19390211.2017.1321079. [Epub ahead of print] PMID: 28489956 </br>5:Stable Benzacridine Pigments by Oxidative Coupling of Chlorogenic Acid with Amino Acids and Proteins: Toward Natural Product-Based Green Food Coloring. Iacomino M, Weber F, Gleichenhagen M, Pistorio V, Panzella L, Pizzo E, Schieber A, d/’Ischia M, Napolitano A.J Agric Food Chem. 2017 May 16. doi: 10.1021/acs.jafc.7b00999. [Epub ahead of print] PMID: 28488442 </br>6:Protective effect of Chlorogenic acid against methotrexate induced oxidative stress inflammation and apoptosis in rat liver: An experimental approach. Ali N, Rashid S, Nafees S, Hasan SK, Shahid A, Majed F, Sultana S.Chem Biol Interact. 2017 May 4. pii: S0009-2797(17)30140-0. doi: 10.1016/j.cbi.2017.05.002. [Epub ahead of print] PMID: 28479099 </br>7:Protective effects of chlorogenic acid in 3-nitropropionic acid induced toxicity and genotoxicity. Alarcón-Herrera N, Flores-Maya S, Bellido B, García-Bores AM, Mendoza E, Ávila-Acevedo G, Hernández-Echeagaray E.Food Chem Toxicol. 2017 May 3. pii: S0278-6915(17)30226-0. doi: 10.1016/j.fct.2017.04.048. [Epub ahead of print] PMID: 28478101 </br>8:Chlorogenic acid inhibits hepatocellular carcinoma in vitro and in vivo. Yan Y, Liu N, Hou N, Dong L, Li J.J Nutr Biochem. 2017 Apr 18;46:68-73. doi: 10.1016/j.jnutbio.2017.04.007. [Epub ahead of print] PMID: 28458139 </br>9:Protection of protein from ruminal degradation by alkali-induced oxidation of chlorogenic acid in sunflower meal. Bongartz V, Böttger C, Wilhelmy N, Schulze-Kaysers N, Südekum KH, Schieber A.J Anim Physiol Anim Nutr (Berl). 2017 Apr 26. doi: 10.1111/jpn.12729. [Epub ahead of print] PMID: 28444794 </br>10:Inhibition effects of chlorogenic acid on benign prostatic hyperplasia in mice. Huang Y, Chen H, Zhou X, Wu X, Hu E, Jiang Z.Eur J Pharmacol. 2017 Apr 14. pii: S0014-2999(17)30278-9. doi: 10.1016/j.ejphar.2017.04.017. [Epub ahead of print] PMID: 28416373 |
