Chloroquine Diphosphate

• CAT Number: A000578
• CAS Number: 50-63-5
• Molecular Formula: C₁₈H₂₆ClN₃·2H₃PO₄
• Molecular Weight: 515.86
• Purity: ≥95%
• Target: Autophagy
• Solubility: Limited solubility
• Storage: Desiccate at RT
• IUPAC Name: 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
• InChI: InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
• InChIKey: QKICWELGRMTQCR-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

Chloroquine Diphosphate（Cat No.:A000578）is a widely used antimalarial drug that targets Plasmodium species responsible for malaria. It acts by interfering with heme detoxification in the parasite’s food vacuole, causing toxic accumulation and death. Beyond malaria, it has been explored for autoimmune diseases like rheumatoid arthritis and lupus due to its immunomodulatory effects. Chloroquine Diphosphate also exhibits antiviral potential, making it a candidate for research into emerging viral infections. Its broad therapeutic applications and established efficacy underscore its importance in medicine and pharmacological research.

Reference

Sullivan, David J. et. al. /On the Molecular Mechanism of Chloroquine/’s Antimalarial Action./ PNAS 93 (1996): 11865-1870. Nih.gov. Web. 2 Oct. 2013.