For research use only. Not for therapeutic Use.
Chloroquine（Cat No.:I015581）is an antimalarial drug that also exhibits anti-inflammatory and antiviral properties. It works by interfering with the parasite’s ability to degrade hemoglobin in red blood cells, effectively stopping its growth. In addition to treating malaria, chloroquine is used to manage autoimmune diseases like rheumatoid arthritis and lupus due to its ability to modulate the immune system. It has also been explored for its potential in cancer and viral infection treatments by inhibiting autophagy. Chloroquine remains a versatile compound in clinical and research settings.
| Catalog Number | I015581 |
| CAS Number | 54-05-7 |
| Molecular Formula | C₁₈H₂₆ClN₃ |
| Purity | ≥95% |
| Storage | 2-8°C(protect from light) |
| IUPAC Name | 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine |
| InChI | InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) |
| InChIKey | WHTVZRBIWZFKQO-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl |
| Reference | [1]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.<br>[2]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.<br>[3]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626.<br>[4]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932.<br>[5]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135. |
