Chlorothiazide

• CAT Number: A000633
• CAS Number: 58-94-6
• Molecular Formula: C7H6ClN3O4S2
• Molecular Weight: 295.72
• Purity: ≥95%
• Synonyms: 6-chloro-1,1-dioxo-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide
• InChI: InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
• InChIKey: JBMKAUGHUNFTOL-UHFFFAOYSA-N
• SMILES: C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2

Chlorothiazide is an orally active diuretic and anti-hypertensive agent[1].
Chlorothiazide has a plasma half-life of 45–120 min and a biological half-life of nearly 10 h[1].

Reference

[1]. Babu V R, et al. Preparation and in-vitro release of chlorothiazide novel pH-sensitive chitosan-N, N′-dimethylacrylamide semi-interpenetrating network microspheres. Carbohydrate Polymers, 2008, 71(2): 208-217.