Chloroxine

• CAT Number: A000829
• CAS Number: 773-76-2
• Molecular Formula: C9H5Cl2NO
• Molecular Weight: 214.05
• Purity: ≥95%
• Synonyms: 5,7-Dichloroquinolin-8-ol; 5,7-Dichloro-8-hydroxyquinoline; 773-76-2; Chlorquinol; Capitrol
• Storage: -20°C
• IUPAC Name: 5,7-dichloroquinolin-8-ol
• InChI: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
• InChIKey: WDFKMLRRRCGAKS-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1

Chloroxine（Cat No.:A000829）is an antibacterial and antifungal agent commonly used in dermatology to treat skin infections, dandruff, and seborrheic dermatitis. It works by disrupting microbial cell membranes and inhibiting essential enzymatic processes, effectively limiting bacterial and fungal growth. Often formulated in shampoos, lotions, or creams, Chloroxine is valued for its broad-spectrum activity and relatively low irritation potential, making it suitable for sensitive skin. Its effectiveness in reducing dandruff and controlling skin conditions has established Chloroxine as a reliable ingredient in personal care and therapeutic dermatological products.

Reference

1: Pérez-Ruiz T, Martínez-Lozano C, Tomás V, Carpena J. Fluorimetric
determination of chloroxine using manual and flow-injection methods. J Pharm
Biomed Anal. 1996 Aug;14(11):1505-11. PubMed PMID: 8877856.

2: Negosanti M, Bettoli V, Valenti R, Patrone P, Celasco G. [Clinical evaluation
on the usefulness of 5,7-dichloro-8-hydroxyquinoline (chloroxine) in association
with betamethasone 17-benzoate in the topical treatment of infected
cortisone-sensitive dermopathies]. G Ital Dermatol Venereol. 1985
Mar-Apr;120(2):XVII-XXIII. Italian. PubMed PMID: 4007946.

3: Johnson ML. Fluorescence with chloroxine shampoo. Arch Dermatol. 1979
May;115(5):641. PubMed PMID: 443855.

4: Stocchi F. [Clinical tests of topical preparations containing betamethasone
17-benzoate and the same associated with 5,7-dichloro-8-hydroxyquinoline
(chloroxine)]. Clin Ter. 1977 Nov 30;83(4):359-69. Italian. PubMed PMID: 603986.

5: Chládek S, Zemlicka J, Gut V. 5-chloro-8-hydroxyquinoline (chloroxine) esters
of carboxylic acid–selective reagents for acylation of nucleoside and nucleotide
aminoacyl derivatives. Biochem Biophys Res Commun. 1969 Apr 29;35(2):306-11.
PubMed PMID: 5772585.