Chlorphenesin carbamate

• CAT Number: I006108
• CAS Number: 886-74-8
• Molecular Formula: C10H12ClNO4
• Molecular Weight: 245.66
• Purity: ≥95%
• Synonyms: [3-(4-chlorophenoxy)-2-hydroxypropyl] carbamate
• InChI: InChI=1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14)
• InChIKey: SKPLBLUECSEIFO-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1OCC(COC(=O)N)O)Cl

Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant. Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation[1]. Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels[2]. Antinociceptive effect[3].
Chlorphenesin carbamate (CPC; 50 mg/kg i.v.) inhibits the mono (MSR) and poly-synaptic reflex (PSR), the latter being more susceptible than the former to CPC depression. Chlorphenesin carbamate has an apparent depressant action on the spinal neuron, and it hyperpolarized both the ventral and dorsal roots of the isolated frog spinal cord[2].
Chlorphenesin carbamate (CPC) has an antinociceptive action in adjuvant arthritic rats. Chlorphenesin carbamate (100-400 mg/kg, p.o.) has a dose-dependent antinociceptive effect in the behavioral study. Chlorphenesin carbamate (25-50 mg/kg, i.v.) depresses the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB) in the electrophysiological study. Chlorphenesin carbamate (50 mg/kg, i.v.) depresses the spontaneous firings of the VB nociceptive neurons[3].

Reference

[1]. Ji-young Yu, et al. Relative bioavailability of generic and branded 250-mg and 500-mg oral chlorphenesin carbamate tablets in healthy Korean volunteers: a single-dose, randomized-sequence, open-label, two-period crossover trial. Clin Ther. 2009 Nov;31(11)
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[2]. M Kurachi, et al. Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13.
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[3]. S Okuyama, et al. Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats. Res Commun Chem Pathol Pharmacol. 1987 Feb;55(2):147-60.
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