Chlorthalidone-d4

• CAT Number: R056330
• CAS Number: 1794941-44-8
• Molecular Formula: C14H11ClN2O4S
• Molecular Weight: 342.786
• Purity: ≥95%
• Synonyms: 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide-d4; 3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine-d4; Chlorthalidon-d4; Chlorthalidone-d4; Hygroton-d4; Igroton-d4; Phthalamudine-d4; Zambesil-d4; NSC 69200-d4
• Storage: -20°C
• Related CAS: 77-36-1 (unlabeled)
• IUPAC Name: 2-chloro-5-(4,5,6,7-tetradeuterio-1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
• InChI: InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)/i1D,2D,3D,4D
• InChIKey: JIVPVXMEBJLZRO-RHQRLBAQSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O

Chlorthalidone-d4 is a deuterated form of chlorthalidone, a thiazide-like diuretic used to treat hypertension and edema. In this version, four hydrogen atoms are replaced with deuterium. The deuterium labeling allows for precise tracking and analysis of the drug in pharmacokinetic and metabolic studies using mass spectrometry. This enables researchers to better understand the absorption, distribution, metabolism, and excretion of chlorthalidone in the body. Chlorthalidone-d4 is valuable in drug research, helping to optimize dosing, reduce side effects, and study drug interactions.