Cholecystokinin Octapeptide, desulfated TFA

• CAT Number: I009877
• CAS Number: 171486-94-5
• Molecular Formula: C51H63F3N10O15S2
• Molecular Weight: 1177.23
• Purity: ≥95%
• Synonyms: (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C49H62N10O13S2.C2HF3O2/c1-73-18-16-34(55-47(70)37(21-28-12-14-30(60)15-13-28)58-44(67)32(50)23-41(62)63)45(68)53-26-40(61)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(71)56-35(17-19-74-2)46(69)59-39(24-42(64)65)49(72)57-36(43(51)66)20-27-8-4-3-5-9-27;3-2(4,5)1(6)7/h3-15,25,32,34-39,52,60H,16-24,26,50H2,1-2H3,(H2,51,66)(H,53,68)(H,54,61)(H,55,70)(H,56,71)(H,57,72)(H,58,67)(H,59,69)(H,62,63)(H,64,65);(H,6,7)/t32-,34-,35-,36-,37-,38-,39-;/m0./s1
• InChIKey: HTIRPVYNGDRDRP-ITZXPNBCSA-N
• SMILES: CSCCC(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(=O)O)N.C(=O)(C(F)(F)F)O

Cholecystokinin Octapeptide, desulfated TFA is a synthetic analog of the gastrointestinal hormone cholecystokinin (CCK), specifically the octapeptide segment, but lacking the natural sulfate group. This modification affects its biological activity, particularly in binding to CCK receptors. Cholecystokinin plays a crucial role in digestion by stimulating the release of digestive enzymes from the pancreas and bile from the gallbladder. The desulfated version is used in research to study the role of sulfation in CCK receptor interaction and its effects on digestion and appetite regulation.