Cholesterol 24-hydroxylase-IN-1

• CAT Number: I044053
• CAS Number: 1613480-70-8
• Molecular Formula: C17H23N5O
• Molecular Weight: 313.40
• Purity: ≥95%
• Synonyms: N,N-dimethyl-1-[4-(4-methylpyrazol-1-yl)pyridin-3-yl]piperidine-4-carboxamide
• InChI: InChI=1S/C17H23N5O/c1-13-10-19-22(12-13)15-4-7-18-11-16(15)21-8-5-14(6-9-21)17(23)20(2)3/h4,7,10-12,14H,5-6,8-9H2,1-3H3
• InChIKey: MYSVNUHQXQZBQE-UHFFFAOYSA-N
• SMILES: CC1=CN(N=C1)C2=C(C=NC=C2)N3CCC(CC3)C(=O)N(C)C

Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier[1].

Reference

[1]. Kajita Y, et al. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J Med Chem. 2022;65(4):3343-3358.
 [Content Brief]