For research use only. Not for therapeutic Use.
Cholic acid, also known as Cholalin and Orphacol, is a bile acid used to treat inborn errors of primary bile acid synthesis. Cholic acid It facilitates fat absorption and cholesterol excretion. Cholic acid is produced in the liver and usually conjugated with glycine or taurine.
| Catalog Number | R012539 |
| CAS Number | 81-25-4 |
| Synonyms | (3α,5β,7α12α)-3,7,12-Trihydroxy-cholan-24-oic Acid; 17β-(1-Methyl-3-carboxy-propyl)etiocholane-3α,7α,12α-triol;?5β-Cholic Acid; Cholalic Acid; Cholalin; Colalin; NSC-6135; |
| Molecular Formula | C24H40O5 |
| Purity | ≥95% |
| Storage | Room temperature |
| InChIKey | BHQCQFFYRZLCQQ-OELDTZBJSA-N |
| Reference | </br>1:Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs. Yamada S, Kawaguchi H, Yamada T, Guo X, Matsuo K, Hamada T, Miura N, Tasaki T, Tanimoto A.J Atheroscler Thromb. 2017 May 11. doi: 10.5551/jat.39909. [Epub ahead of print] PMID: 28496045 Free Article</br>2:Cholic acid-based novel micellar nanoplatform for delivering FDA-approved taxanes. Bharadwaj G, Nhan V, Yang S, Li X, Narayanan A, Macarenco AC, Shi Y, Yang D, Vieira LS, Xiao W, Li Y, Lam KS.Nanomedicine (Lond). 2017 May;12(10):1153-1164. doi: 10.2217/nnm-2017-0361. Epub 2017 Apr 27. PMID: 28447909 </br>3:Mechanism of hepatic targeting via oral administration of DSPE-PEG-cholic acid-modified nanoliposomes. Li Y, Zhu C.Int J Nanomedicine. 2017 Feb 28;12:1673-1684. doi: 10.2147/IJN.S125047. eCollection 2017. PMID: 28280334 Free PMC Article</br>4:Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration. Miura T, Tachikawa M, Ohtsuka H, Fukase K, Nakayama S, Sakata N, Motoi F, Naitoh T, Katayose Y, Uchida Y, Ohtsuki S, Terasaki T, Unno M.J Pharm Sci. 2017 Feb 27. pii: S0022-3549(17)30127-2. doi: 10.1016/j.xphs.2017.02.018. [Epub ahead of print] PMID: 28249806 </br>5:Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Pan X, Kent R, Won KJ, Jeong H.Drug Metab Dispos. 2017 Apr;45(4):346-352. doi: 10.1124/dmd.116.074013. Epub 2017 Feb 2. PMID: 28153841 </br>6:/Bitter-Sweet/ Polymeric Micelles Formed by Block Copolymers from Glucosamine and Cholic Acid. Zhang K, Jia YG, Tsai IH, Strandman S, Ren L, Hong L, Zhang G, Guan Y, Zhang Y, Zhu XX.Biomacromolecules. 2017 Mar 13;18(3):778-786. doi: 10.1021/acs.biomac.6b01640. Epub 2017 Feb 24. PMID: 28094989 </br>7:Cationic gemini surfactant as a dual linker for a cholic acid-modified polysaccharide in aqueous solution: thermodynamics of interaction and phase behavior. Bai G, Wu H, Lou P, Wang Y, Nichifor M, Zhuo K, Wang J, Bastos M.Phys Chem Chem Phys. 2017 Jan 4;19(2):1590-1600. doi: 10.1039/c6cp07212g. PMID: 27990515 </br>8:Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL.Hepatology. 2016 Dec;64(6):2151-2164. doi: 10.1002/hep.28826. Epub 2016 Oct 28. PMID: 27639250 </br>9:Magnetically Alignable Bicelles with Unprecedented Stability Using Tunable Surfactants Derived from Cholic Acid. Matsui R, Uchida N, Ohtani M, Yamada K, Shigeta A, Kawamura I, Aida T, Ishida Y.Chemphyschem. 2016 Dec 5;17(23):3916-3922. doi: 10.1002/cphc.201600897. Epub 2016 Sep 30. PMID: 27553850 </br>10:Cholic acid therapy in Zellweger spectrum disorders. Berendse K, Klouwer FC, Koot BG, Kemper EM, Ferdinandusse S, Koelfat KV, Lenicek M, Schaap FG, Waterham HR, Vaz FM, Engelen M, Jansen PL, Wanders RJ, Poll-The BT.J Inherit Metab Dis. 2016 Nov;39(6):859-868. Epub 2016 Jul 28. PMID: 27469511 Free PMC Article |
