For research use only. Not for therapeutic Use.
Choline fenofibrate (Cat.No:I005140), with CAS number 856676-23-8, is a medication used to treat high cholesterol and triglyceride levels in the blood. It is a combination of fenofibrate, a lipid-regulating agent, and choline, a water-soluble nutrient. Choline fenofibrate works by reducing the production of triglycerides and increasing the levels of good cholesterol (HDL) in the bloodstream.
| Catalog Number | I005140 |
| CAS Number | 856676-23-8 |
| Synonyms | 2-hydroxy-N,N,N-trimethylethanaminium 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate |
| Molecular Formula | C22H28ClNO5 |
| Purity | ≥95% |
| Target | IκB/IKK |
| Solubility | DMSO: ≤ 6.2 mg/mL (Need ultrasonic and warming) |
| Storage | Store at -20°C |
| IUPAC Name | 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate;2-hydroxyethyl(trimethyl)azanium |
| InChI | InChI=1S/C17H15ClO4.C5H14NO/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11;1-6(2,3)4-5-7/h3-10H,1-2H3,(H,20,21);7H,4-5H2,1-3H3/q;+1/p-1 |
| InChIKey | JWAZHODZSADEHB-UHFFFAOYSA-M |
| SMILES | CC(C)(C(=O)[O-])OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl.C[N+](C)(C)CCO |
| Reference | </br>1:Choline Fenofibrate Delayed Release Capsules Versus Conventional Fenofibrate Tablets for Dyslipidemia: A Randomized, Non-Inferiority Trial. Agarwal M, Singh VB, Garg P, Rijhwani P, Agrawal N, Tak S, Mittal R, Daultani P, Pawar P.J Assoc Physicians India. 2015 Aug;63(8):20-6. No abstract available. PMID: 27604432 </br>2:Absolute oral bioavailability of fenofibric acid and choline fenofibrate in rats determined by ultra-performance liquid chromatography tandem mass spectrometry. Wei X, Li P, Liu M, Du Y, Wang M, Zhang J, Wang J, Liu H, Liu X.Biomed Chromatogr. 2017 Apr;31(4). doi: 10.1002/bmc.3832. Epub 2016 Oct 10. PMID: 27594083 </br>3:Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population. Patel P, Barkate H.Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):67-71. doi: 10.4103/2230-8210.172243. PMID: 26904471 Free PMC Article</br>4:Novel fenofibric acid-loaded controlled release pellet bioequivalent to choline fenofibrate-loaded commercial product in beagle dogs. Kim KS, Jin SG, Mustapha O, Yousaf AM, Kim DW, Kim YH, Kim JO, Yong CS, Woo JS, Choi HG.Int J Pharm. 2015 Jul 25;490(1-2):273-80. doi: 10.1016/j.ijpharm.2015.05.059. Epub 2015 May 27. PMID: 26024820 |
