CHR-6494

• CAT Number: I001272
• CAS Number: 1333377-65-3
• Molecular Formula: C16H16N6
• Molecular Weight: 292.34
• Purity: ≥95%
• Synonyms: 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine
• Target: Haspin Kinase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: N/A
• InChI: InChI=1S/C16H16N6/c1-2-7-17-15-5-6-16-18-10-14(22(16)21-15)11-3-4-13-12(8-11)9-19-20-13/h3-6,8-10H,2,7H2,1H3,(H,17,21)(H,19,20)
• InChIKey: CZZCAOGIEGXMBZ-UHFFFAOYSA-N
• SMILES: CCCNC1=NN2C(=NC=C2C3=CC4=C(C=C3)NN=C4)C=C1

CHR-6494（Cat No.:I001272）is an investigational small molecule that acts as a selective antagonist of the CCR2 receptor, a chemokine receptor involved in recruiting inflammatory cells, particularly monocytes, to sites of injury or infection. By inhibiting CCR2, CHR-6494 aims to reduce inflammation and tissue damage, making it a promising candidate for treating chronic inflammatory diseases, such as rheumatoid arthritis, atherosclerosis, and certain autoimmune disorders. Preclinical studies have shown its potential to modulate immune responses and reduce inflammation, though further clinical trials are needed to evaluate its safety, efficacy, and long-term therapeutic potential.

Reference

[1]. Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis et al. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorganic & Medicinal Chemistry Letters (2012), 22(5), 2015-2019.
[2]. Huertas, D.; Soler, M.; Moreto, J. et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene (2012), 31(11), 1408-1418.
[3]. Wang F, Ulyanova NP, Daum JR et al. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol. 2012 Oct 15;199(2):251-68.