Chrodrimanin B

• CAT Number: I024621
• CAS Number: 132196-54-4
• Molecular Formula: C27H32O8
• Molecular Weight: 484.55
• Purity: 95%
• Synonyms: Chrodrimanin B, Thailandolide B
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1R,2R,7aR,8S,9aR,13aS,13bS)-1-(acetyloxy)-1,8,9,9a,10,13a,13b,14-octahydro-5,8-dihydroxy-2,7a,10,10,13a-pentamethyl-2H,4H-benzo[a]pyrano[3,4-j]xanthene-4,11(7aH)-dione
• InChI: InChI=1S/C27H32O8/c1-12-23(34-13(2)28)21-14-9-18-26(5)8-7-19(30)25(3,4)17(26)11-20(31)27(18,6)35-16(14)10-15(29)22(21)24(32)33-12/h7-8,10,12,17-18,20,23,29,31H,9,11H2,1-6H3/t12-,17+,18+,20+,23+,26+,27-/m1/s1
• InChIKey: DYQKBALSPZQWQD-FWEFFTEASA-N
• SMILES: O=C(C)O[C@H]1[C@@H](C)OC(C2=C1C3=C(C=C2O)O[C@@]([C@@]4([H])C3)(C)[C@@H](O)C[C@@]([C@]4(C)C=C5)([H])C(C)(C)C5=O)=O

Chrodrimanin B(CAT: I024621) is a meroterpenoid compound isolated from fungi such as Aspergillus and Penicillium. It exhibits potent insecticidal properties by antagonizing the insect γ-aminobutyric acid (GABA) receptor RDL with high selectivity (IC₅₀ of 1.13 nM). Structurally complex, it features fused rings with hydroxyl and ester groups, contributing to its bioactivity. While Chrodrimanin B disrupts neurotransmission in insects, leading to paralysis, it has minimal effect on human GABA receptors (IC₅₀ of 1.48 μM), making it a promising lead for insect-specific neuroactive agents. Its selective action and biosynthetic pathway have made it a key subject in entomological research.