chroman 1

• CAT Number: I001093
• CAS Number: 1273579-40-0
• Molecular Formula: C24H28N4O4
• Molecular Weight: 436.51
• Purity: ≥95%
• Synonyms: (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide
• Target: TGF-beta/Smad
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C24H28N4O4/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29)/t18-/m0/s1
• InChIKey: ROFMCPHQNWGXGE-SFHVURJKSA-N
• SMILES: CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)[C@H]3CC4=C(C=CC(=C4)OC)OC3

Chroman 1(CAT: I001093) is a potent and selective ATP-competitive inhibitor of the mitotic kinase Aurora A, widely utilized in cancer research. By targeting Aurora A, Chroman 1 disrupts key processes in cell division, such as spindle assembly and chromosome alignment, leading to mitotic arrest and apoptosis in cancer cells. This compound is particularly valuable for studying the role of Aurora A in tumorigenesis and its potential as a therapeutic target. With high specificity and efficacy, Chroman 1 is suitable for in vitro and in vivo studies, advancing the development of targeted therapies for Aurora A-dependent malignancies.