Ciclopirox

• CAT Number: A000768
• CAS Number: 29342-05-0
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.30
• Purity: ≥95%
• Target: Apoptosis
• Storage: 3 years -20C powder
• IUPAC Name: 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
• InChI: InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3
• InChIKey: SCKYRAXSEDYPSA-UHFFFAOYSA-N
• SMILES: CC1=CC(=O)N(C(=C1)C2CCCCC2)O

Ciclopirox（Cat No.:A000768）is a broad-spectrum antifungal agent used in the treatment of various dermatological and nail infections. It inhibits fungal cell membrane synthesis by chelating metal ions, disrupting cell function, and impairing cellular respiration. Ciclopirox is effective against dermatophytes, yeasts, and molds, and is commonly prescribed for conditions like athlete’s foot, ringworm, and seborrheic dermatitis. Available in topical formulations such as creams, lotions, and nail lacquers, Ciclopirox is considered a safe, effective option for localized fungal infections. It offers a favorable side effect profile, making it a valuable treatment option in dermatology.

Overview of Clinical Research

Ciclopirox is a cell cycle inhibitor, DNA repair inhibitor and DNA synthesis inhibitor. It has been granted for the new molecular entity. 

Reference

1.Łowicki, Daniel, and Adam Huczyński. "Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements." BioMed research international 2013 (2013).
2.Baby, Santhosh M., et al. "Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1α and-1β in the rat carotid body and glomus cells." Histochemistry and cell biology 120.5 (2003): 343-352.