CID-2011756

  • CAT Number: I004410
  • CAS Number: 638156-11-3
  • Molecular Formula: C₂₂H₂₁ClN₂O₃
  • Molecular Weight: 396.87
  • Purity: ≥95%
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CID-2011756 (Cat.No:I004410) is a small molecule inhibitor that targets the p38 MAP kinase pathway. It has been studied for its potential therapeutic applications in various diseases, including inflammation, cancer, and neurodegenerative disorders. CID-2011756 selectively inhibits the activity of p38α and p38β isoforms, which are involved in cellular signaling pathways associated with inflammation and stress response. Preclinical studies have shown promising results, making CID-2011756 a potential candidate for further development as a therapeutic agent.


Catalog Number I004410
CAS Number 638156-11-3
Synonyms

5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide

Molecular Formula C₂₂H₂₁ClN₂O₃
Purity ≥95%
Target Protein Ser/Thr Phosphatases
Solubility DMSO: 50 mM
Storage Store at RT
IC50 10±0.7 uM (cellular inhibition of phospho-Ser916-PKD1 activity) [1]
IUPAC Name 5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
InChI nChI=1S/C22H21ClN2O3/c23-18-3-1-2-17(14-18)20-8-9-21(28-20)22(26)24-19-6-4-16(5-7-19)15-25-10-12-27-13-11-25/h1-9,14H,10-13,15H2,(H,24,26)
InChIKey XQJWTJLJEYIUDZ-UHFFFAOYSA-N
SMILES C1COCCN1CC2=CC=C(C=C2)NC(=O)C3=CC=C(O3)C4=CC(=CC=C4)Cl
Reference

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<br>[1]. Sharlow ER, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. 2011;6(10):e25134.
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