CID 2011756

• CAT Number: I013940
• CAS Number: 638156-11-3
• Molecular Formula: C₂₂H₂₁ClN₂O₃
• Molecular Weight: 396.87
• Purity: ≥95%
• Target: PKD
• Solubility: 10 mM in DMSO
• IUPAC Name: 5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
• InChI: InChI=1S/C22H21ClN2O3/c23-18-3-1-2-17(14-18)20-8-9-21(28-20)22(26)24-19-6-4-16(5-7-19)15-25-10-12-27-13-11-25/h1-9,14H,10-13,15H2,(H,24,26)
• InChIKey: XQJWTJLJEYIUDZ-UHFFFAOYSA-N
• SMILES: C1COCCN1CC2=CC=C(C=C2)NC(=O)C3=CC=C(O3)C4=CC(=CC=C4)Cl

CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells.
IC50 Value: 10±0.7 uM (cellular inhibition of phospho-Ser916-PKD1 activity) [1]
Target: PKD
CID 2011756, has pan-PKD inhibitory effects (PKD2 IC50 = 0.6±0.1 uM; PKD3 IC50 = 0.7±0.2 uM) with similar, albeit not identical, potencies which may be expected for an ATP competitive inhibitor. CID 2011756 was the most potent of the inhibitors with a cellular EC50 of 10±0.7 uM (n = 3), an EC50 value comparable to that of our previously described benzoxoloazepinolone.

Reference

[1]. Sharlow ER, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. 2011;6(10):e25134.