For research use only. Not for therapeutic Use.
CID 5157334 is a selective surrogate agonist for GPR27 (pEC50 value of 6.38 for GPR27V2). Structural analog CID 1375606 (Axon 2915) is also available.
The structure of CID 5157334 (Axon 3926) was confirmed by the lead author (Mol Pharmacol. 2017 Jun;91(6):595-608) as the active GPR27 agonist that was tested.
KEYWORDS: CID 5157334 | Supplier | GPR27 agonist | Chembridge ID 5128535 | CID5157334 | CID-5157334 | ID5128535 | ID-5128535 | CAS [651295-98-6] | Non Selective | GPR27 | Agonist | Receptors | SREB1 | β-Arrestin 2
| Catalog Number | I047708 |
| CAS Number | 651295-98-6 |
| Molecular Formula | C19H14Cl2N2O3S |
| Purity | ≥95% |
| IUPAC Name | 2,4-dichloro-N-[4-(phenylsulfamoyl)phenyl]benzamide |
| InChI | InChI=1S/C19H14Cl2N2O3S/c20-13-6-11-17(18(21)12-13)19(24)22-14-7-9-16(10-8-14)27(25,26)23-15-4-2-1-3-5-15/h1-12,23H,(H,22,24) |
| SMILES | C1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)Cl)Cl |
| Reference | N Dupuis et al. Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment. Mol Pharmacol. 2017 Jun;91(6):595-608. |
