Cidofovir

• CAT Number: A000312
• CAS Number: 113852-37-2
• Molecular Formula: C8H14N3O6P
• Molecular Weight: 279.20
• Purity: ≥95%
• Synonyms: Vistide; 113852-37-2; HPMPC; Cidofovir anhydrous; (S)-HPMPC
• Target: Apoptosis
• Solubility: Limited solubility
• Storage: -20°C
• IUPAC Name: [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid
• InChI: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
• InChIKey: VWFCHDSQECPREK-LURJTMIESA-N
• SMILES: C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O

Cidofovir（Cat No.:A000312）is an antiviral medication used primarily in the treatment of cytomegalovirus (CMV) infections, particularly in immunocompromised patients such as those with HIV/AIDS. It works by inhibiting viral DNA polymerase, preventing viral replication. Cidofovir is effective against a range of DNA viruses, including herpesviruses. Its use is typically reserved for severe CMV infections due to its nephrotoxic effects. As a nucleotide analogue, Cidofovir requires intravenous administration and is often combined with probenecid to reduce nephrotoxicity. It’s critical to monitor kidney function during treatment to mitigate adverse effects.

Reference

1: Smith SDB, Erdag G, Cuda JD, Rangwala S, Girardi N, Bibee K, Orens JB,
Dioverti Prono M, Toptan T, Loss MJ. Treatment of human polyomavirus-7 associated
rash and pruritus with topical cidofovir in a lung transplant patient: Case
report and literature review. Transpl Infect Dis. 2017 Oct 24. doi:
10.1111/tid.12793. [Epub ahead of print] PubMed PMID: 29064138.

2: Jones SEF, Hibbitts S, Hurt CN, Bryant D, Fiander AN, Powell N, Tristram AJ.
Human Papillomavirus DNA Methylation Predicts Response to Treatment Using
Cidofovir and Imiquimod in Vulval Intraepithelial Neoplasia 3. Clin Cancer Res.
2017 Sep 15;23(18):5460-5468. doi: 10.1158/1078-0432.CCR-17-0040. Epub 2017 Jun
9. PubMed PMID: 28600473.

3: Arora R, Jasmita, Singh M, Garg A, Gupta M, Gupta N. Successful Treatment of
BK Virus Hemorrhagic Cystitis (HC) Post Allogenic Hematopoietic Stem Cell
Transplantation with Low Dose Cidofovir. J Assoc Physicians India. 2017
May;65(5):93-94. PubMed PMID: 28598058.

4: Vora SB, Brothers AW, Englund JA. Renal Toxicity in Pediatric Patients
Receiving Cidofovir for the Treatment of Adenovirus Infection. J Pediatric Infect
Dis Soc. 2017 Apr 17. doi: 10.1093/jpids/pix011. [Epub ahead of print] PubMed
PMID: 28419263.

5: Ip MH, Coroneo MT. Treatment of Previously Refractory Ocular Surface Squamous
Neoplasia With Topical Cidofovir. JAMA Ophthalmol. 2017 May 1;135(5):500-502.
doi: 10.1001/jamaophthalmol.2017.0365. PubMed PMID: 28358964.

6: Meacham RK, Thompson JW. Comparison of cidofovir and the measles, mumps, and
rubella vaccine in the treatment of recurrent respiratory papillomatosis. Ear
Nose Throat J. 2017 Feb;96(2):69-74. PubMed PMID: 28231366.

7: Catalani S, Palma F, Battistelli S, Nuvoli B, Galati R, Benedetti S. Reduced
cell viability and apoptosis induction in human thyroid carcinoma and
mesothelioma cells exposed to cidofovir. Toxicol In Vitro. 2017 Jun;41:49-55.
doi: 10.1016/j.tiv.2017.02.008. Epub 2017 Feb 20. PubMed PMID: 28223140.

8: Pi Sala N, Figueras Suriol A, Ramió Montero E. [Intralesional cidofovir in
human papilomavirus infection in interdigital spaces]. Farm Hosp. 2017 Jan
1;41(n01):132-133. doi: 10.7399/fh.2017.41.1.10645. Spanish. PubMed PMID:
28045657.

9: Ganapathi L, Arnold A, Jones S, Patterson A, Graham D, Harper M, Levy O. Use
of cidofovir in pediatric patients with adenovirus infection. Version 2.
F1000Res. 2016 Apr 26 [revised 2016 Jan 1];5:758. doi:
10.12688/f1000research.8374.2. eCollection 2016. PubMed PMID: 27239277; PubMed
Central PMCID: PMC4863673.

10: Lee M, Kim S, Kwon OJ, Kim JH, Jeong I, Son JW, Na MJ, Yoon YS, Park HW, Kwon
SJ. Treatment of Adenoviral Acute Respiratory Distress Syndrome Using Cidofovir
With Extracorporeal Membrane Oxygenation. J Intensive Care Med. 2017
Mar;32(3):231-238. doi: 10.1177/0885066616681272. Epub 2016 Nov 30. Review.
PubMed PMID: 27903788.