Cidofovir dihydrate

For research use only, not for therapeutic use.

  • CAT Number: I001840
  • CAS Number: 149394-66-1
  • Molecular Formula: C8H18N3O8P
  • Molecular Weight: 315.218
  • Purity: ≥95%
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Cidofovir dihydrate (CAT: I001840) is a potent antiviral medication used primarily for the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, such as those with AIDS. It is a nucleotide analog that inhibits viral DNA replication by incorporating into the growing DNA chain and terminating its elongation. Cidofovir dihydrate has also shown activity against other DNA viruses, including herpes simplex viruses (HSV) and human papillomaviruses (HPV). It is typically administered intravenously and may be associated with side effects such as nephrotoxicity. Cidofovir dihydrate is a valuable tool in the management of CMV retinitis and other viral infections in certain patient populations.


Catalog Number I001840
CAS Number 149394-66-1
Molecular Formula C8H18N3O8P
Purity ≥95%
Target CMV DNA polymerase
Solubility 10 mM in DMSO
Storage Store at -20°C
Related CAS 113852-37-2(anhydrous)
SMILES n1(C[C@H](OCP(=O)(O)O)CO)c(=O)nc(cc1)N.O.O
Reference

1: Lalezari JP, Drew WL, Glutzer E, James C, Miner D, Flaherty J, Fisher PE,
Cundy K, Hannigan J, Martin JC, et al.
(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a
phase I/II study of a novel antiviral nucleotide analogue. J Infect Dis. 1995
Apr;171(4):788-96. PubMed PMID: 7706804.
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2: Kirsch LS, Arevalo JF, De Clercq E, Chavez de la Paz E, Munguia D, Garcia R,
Freeman WR. Phase I/II study of intravitreal cidofovir for the treatment of
cytomegalovirus retinitis in patients with the acquired immunodeficiency
syndrome. Am J Ophthalmol. 1995 Apr;119(4):466-76. PubMed PMID: 7709971.

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3: Polis MA, Spooner KM, Baird BF, Manischewitz JF, Jaffe HS, Fisher PE, Falloon
J, Davey RT Jr, Kovacs JA, Walker RE, et al. Anticytomegaloviral activity and
safety of cidofovir in patients with human immunodeficiency virus infection and
cytomegalovirus viruria. Antimicrob Agents Chemother. 1995 Apr;39(4):882-6.
PubMed PMID: 7785989; PubMed Central PMCID: PMC162647.
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4: James JS. Cidofovir recommended for approval for CMV retinitis. AIDS Treat
News. 1996 Apr 5;(no 244):6-7. PubMed PMID: 11363308.
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5: de Oliveira CB, Stevenson D, LaBree L, McDonnell PJ, Trousdale MD. Evaluation
of Cidofovir (HPMPC, GS-504) against adenovirus type 5 infection in vitro and in
a New Zealand rabbit ocular model. Antiviral Res. 1996 Jul;31(3):165-72. PubMed
PMID: 8811201.

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