Cidofovir diphosphate tri(triethylamine)

• CAT Number: I042846
• Molecular Formula: C26H61N6O12P3
• Molecular Weight: 742.72
• Purity: ≥95%
• Synonyms: [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid;N,N-diethylethanamine
• InChI: InChI=1S/C8H16N3O12P3.3C6H15N/c9-7-1-2-11(8(13)10-7)3-6(4-12)21-5-24(14,15)22-26(19,20)23-25(16,17)18;3*1-4-7(5-2)6-3/h1-2,6,12H,3-5H2,(H,14,15)(H,19,20)(H2,9,10,13)(H2,16,17,18);3*4-6H2,1-3H3/t6-;;;/m0.../s1
• InChIKey: ACOWIDCBFHAIRH-GSUNZCPGSA-N
• SMILES: CCN(CC)CC.CCN(CC)CC.CCN(CC)CC.C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)OP(=O)(O)OP(=O)(O)O

Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively[1][2].
Cidofovir diphosphate tri triethylamine (0-1000 μM) inhibits HCMV, HSV-1, HSV-2, human α, human β and human γ DNA polymerase with Ki values of 6.6, 0.86, 1.4, 51, 520 and 300 μM, respectively[1].
Cidofovir diphosphate tri triethylamine (0.3-30 μM) inhibits vaccinia virus DNA polymerase with a Km value of 23 μM[2].

Reference

[1]. Hitchcock MJM, et al. Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity. 1996.

[2]. Magee WC, et al. Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrob Agents Chemother. 2005 Aug;49(8):3153-62.
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