For research use only. Not for therapeutic Use.
Cilazapril Monohydrate is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.<br>Cilazapril (1 mg/kg, daily) tends to decrease and the higher dose (10 mg/kg, daily) significantly decreases systolic blood pressure (SBP) in subtotal nephrectomized rats. Cilazapril attenuates the further development of protein uria in a dose-dependent manner in subtotal nephrectomized rats. Cilazapril attenuates the increase in plasma fibrinogen concentration and serum albumin concentration in a dose-dependent manner. Cilazapril reduces serum MCP-1 concentration in the nephrectomized rats. Cilazapril decreases hepatic fibrinogen synthesis through the alleviation of the local inflammatory process and the improvement of hypoalbuminemia.
| Catalog Number | A001064 |
| CAS Number | 92077-78-6 |
| Synonyms | NA |
| Molecular Formula | C22H31N3O5.H2O |
| Purity | ≥95% |
| Target | Angiotensin-converting Enzyme (ACE) |
| Storage | 3 years -20C powder |
