Cilengitide trifluoroacetate

• CAT Number: I004160
• CAS Number: 199807-35-7
• Molecular Formula: C29H41F3N8O9
• Molecular Weight: 702.68
• Purity: ≥95%
• Target: Autophagy
• Storage: -20°C
• IUPAC Name: 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C27H40N8O7.C2HF3O2/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16;3-2(4,5)1(6)7/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30);(H,6,7)/t17-,18-,19+,22-;/m0./s1
• InChIKey: WHJCSACXAPYNTG-LOPTWHKWSA-N
• SMILES: CC(C)C1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N.C(=O)(C(F)(F)F)O

Cilengitide (Cat No.:I004160) is a highly potent inhibitor of the αvβ3 and αvβ5 integrin receptors, with inhibitory concentration (IC50) values of 4.1 nM and 79 nM, respectively, in cell-free assays. It exhibits approximately 10-fold selectivity towards these integrin receptors compared to gpIIbIIIa. By targeting αvβ3 and αvβ5 integrins, Cilengitide interferes with cell adhesion and signaling processes involved in angiogenesis and tumor growth. This integrin inhibitor has shown promise as a potential therapeutic agent in the treatment of cancer and other diseases associated with dysregulated integrin signaling.