Ciliobrevin A

• CAT Number: I003058
• CAS Number: 302803-72-1
• Molecular Formula: C17H9Cl2N3O2
• Molecular Weight: 358.21
• Purity: ≥95%
• Synonyms: (2E)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-1H-quinazolin-2-ylidene)propanenitrile
• Target: Hedgehog
• Solubility: DMSO: ≥ 34 mg/mL
• Storage: Store at +4C
• IUPAC Name: (Z)-3-(2,4-dichlorophenyl)-3-hydroxy-2-(4-oxo-3H-quinazolin-2-yl)prop-2-enenitrile
• InChI: InChI=1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,23H,(H,21,22,24)/b15-12-
• InChIKey: SESYPWCSIZUIAS-VBKFSLOCSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)NC(=N2)/C(=C(/C3=C(C=C(C=C3)Cl)Cl)\O)/C#N

Ciliobrevin A(CAT: I003058) is a potent and selective inhibitor of dynein, a motor protein critical for intracellular transport and mitotic spindle assembly. By targeting dynein ATPase activity, this compound effectively disrupts microtubule-based processes, offering unique insights into cellular dynamics and mechanisms of movement. Its ability to interfere with retrograde transport makes it invaluable for studies in neurobiology, cancer, and infectious disease research. With high specificity and reliability, Ciliobrevin A serves as an essential tool for elucidating the roles of dynein in various cellular pathways. Ideal for advanced biochemical and pharmaceutical studies, this inhibitor is a cornerstone in motor protein research.