For research use only. Not for therapeutic Use.
Cilostazol(Cat No.:A000281)is a phosphodiesterase III (PDE3) inhibitor used primarily to treat intermittent claudication, a condition caused by poor blood circulation in the legs. By inhibiting PDE3, Cilostazol increases cyclic AMP (cAMP) levels, leading to vasodilation and inhibition of platelet aggregation. This dual action improves blood flow and reduces the risk of blood clots. Cilostazol is also used for preventing strokes and managing peripheral arterial disease. Its ability to enhance circulation and prevent clot formation makes it a valuable therapeutic agent for cardiovascular and vascular health.
CAS Number | 73963-72-1 |
Synonyms | 73963-72-1; Pletal; Cilostazole; Pletaal; Cilostazolum |
Molecular Formula | C₂₀H₂₇N₅O₂ |
Purity | ≥95% |
Target | Autophagy |
Solubility | >15.4mg/mL in DMSO |
Storage | -20°C |
IUPAC Name | 6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one |
InChI | InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) |
InChIKey | RRGUKTPIGVIEKM-UHFFFAOYSA-N |
SMILES | C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4 |
Reference | 1: Oguchi T, Ono R, Tsuji M, Shozawa H, Somei M, Inagaki M, Mori Y, Yasumoto T, 2: Ohtomo R, Bannai T, Ohtomo G, Shindo A, Tomimoto H, Tsuji S, Iwata A. <br> <br> 5: Oelze M, Welschof P, Knorr M, Tran LP, Ullmann E, Stamm P, Kröller-Schön S, <br> 7: Galyfos G, Sianou A. Cilostazol for Secondary Prevention of Stroke: Should the 8: Holland PR, Strother L. Cilostazol as a chemically induced preclinical model 9: Christensen SL, Petersen S, Sørensen DB, Olesen J, Jansen-Olesen I. Cilostazol <br> |
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