Ciluprevir, also known as BILN 2061, is a potent and selective HCV NS3 protease inhibitor with proven antiviral effect in humans. In vitro sensitivity studies with BILN 2061 showed a decrease in affinity for proteases of genotypes 2 and 3 (K(i), 80 to 90 nM) compared to genotype 1 enzymes (K(i), 1.5 nM). BILN 2061 may be an antiviral agent for individuals infected with non-genotype-1 HCV.
| Catalog Number | I006005 |
| CAS Number | 300832-84-2 |
| Synonyms | BILN 2061; BILN-2061; BILN2061; BILN-2061ZW; BILN2061ZW; BILN 2061ZW; Ciluprevir;(2R,6S,13aS,14aR,16aS,Z)-6-(((cyclopentyloxy)carbonyl)amino)-2-((2-(2-(isopropylamino)thiazol-4-yl)-7-methoxyquinolin-4-yl)oxy)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15, |
| Molecular Formula | C40H50N6O8S |
| Purity | 95% |
| Target | HCV Protease |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| InChI | InChI=1S/C40H50N6O8S/c1-23(2)41-38-43-32(22-55-38)31-19-34(28-16-15-26(52-3)17-30(28)42-31)53-27-18-33-35(47)45-40(37(49)50)20-24(40)11-7-5-4-6-8-14-29(36(48)46(33)21-27)44-39(51)54-25-12-9-10-13-25/h7,11,15-17,19,22-25,27,29,33H,4-6,8-10,12-14,18,20-21H2 |
| InChIKey | PJZPDFUUXKKDNB-KNINVFKUSA-N |
| SMILES | O=C([C@]([C@]1([H])/C=CCCCCC[C@@H]2NC(OC3CCCC3)=O)(C1)NC([C@@](C[C@@H](OC4=CC(C5=CSC(NC(C)C)=N5)=NC6=CC(OC)=CC=C46)C7)([H])N7C2=O)=O)O |
