For research use only. Not for therapeutic Use.
Cimpuciclib tosylate（Cat No.:I042966）is an investigational small molecule inhibitor targeting cyclin-dependent kinase 9 (CDK9), an enzyme involved in regulating transcriptional elongation and RNA synthesis. By inhibiting CDK9, Cimpuciclib tosylate interferes with the transcription of genes essential for cancer cell survival, leading to cell cycle arrest and apoptosis in rapidly proliferating tumor cells. It is being studied for its potential as an anticancer agent, particularly in the treatment of hematologic cancers and solid tumors. Ongoing research is focused on evaluating its safety, efficacy, pharmacokinetics, and its role in combination therapies.
| CAS Number | 2408872-84-2 |
| Synonyms | [4-(cyclopropylamino)piperidin-1-yl]-[6-[[5-fluoro-4-(2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-2-methylpyridin-3-yl]methanone;4-methylbenzenesulfonic acid |
| Molecular Formula | C37H43FN8O4S |
| Purity | ≥95% |
| IUPAC Name | [4-(cyclopropylamino)piperidin-1-yl]-[6-[[5-fluoro-4-(2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-yl]amino]-2-methylpyridin-3-yl]methanone;4-methylbenzenesulfonic acid |
| InChI | InChI=1S/C30H35FN8O.C7H8O3S/c1-17(2)39-19(4)34-25-9-5-20(15-26(25)39)28-24(31)16-32-30(37-28)36-27-10-8-23(18(3)33-27)29(40)38-13-11-22(12-14-38)35-21-6-7-21;1-6-2-4-7(5-3-6)11(8,9)10/h5,8-10,15-17,21-22,35H,6-7,11-14H2,1-4H3,(H,32,33,36,37);2-5H,1H3,(H,8,9,10) |
| InChIKey | GHPZVWMOCAVFLC-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=C(C=CC(=N1)NC2=NC=C(C(=N2)C3=CC4=C(C=C3)N=C(N4C(C)C)C)F)C(=O)N5CCC(CC5)NC6CC6 |
