Cinaciguat

• CAT Number: I006133
• CAS Number: 329773-35-5
• Molecular Formula: C36H39NO5
• Molecular Weight: 565.71
• Purity: ≥95%
• Synonyms: BAY 582667; BAY-582667; BAY582667; BAY 58-2667; BAY-58-2667; BAY58-2667; Cinaciguat;2-(((4-carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: 4-[[4-carboxybutyl-[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid
• InChI: InChI=1S/C36H39NO5/c38-35(39)16-8-9-24-37(26-32-13-4-6-14-33(32)36(40)41)25-23-31-12-5-7-15-34(31)42-27-30-21-19-29(20-22-30)18-17-28-10-2-1-3-11-28/h1-7,10-15,19-22H,8-9,16-18,23-27H2,(H,38,39)(H,40,41)
• InChIKey: IUKRYDSBNDAYTR-UHFFFAOYSA-N
• SMILES: O=C(O)C1=CC=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3

Cinaciguat(CAT: I006133) is a potent activator of soluble guanylate cyclase (sGC), an enzyme that converts GTP to cyclic GMP, a key signaling molecule involved in vascular relaxation and cardiovascular regulation. Unlike nitric oxide (NO)-dependent sGC activators, Cinaciguat targets the oxidized or heme-free form of sGC, making it effective even under oxidative stress conditions where NO signaling is impaired. It has shown potential in treating heart failure, pulmonary hypertension, and other conditions associated with endothelial dysfunction. Cinaciguat is widely studied in cardiovascular research to explore novel therapeutic approaches for managing diseases linked to impaired NO-sGC-cGMP signaling pathways.