For research use only. Not for therapeutic Use.
Cinalukast（Cat No.:R007874）, is a selective leukotriene D4 receptor antagonist used in the treatment of asthma and allergic rhinitis. By blocking the effects of leukotrienes, which are inflammatory molecules, cinalukast helps reduce airway constriction, inflammation, and mucus production, alleviating asthma symptoms and allergic reactions. It is administered orally and is particularly effective in cases where other treatments are not sufficient. Cinalukast’s targeted action on specific receptors makes it a valuable tool in managing these conditions, offering relief to individuals affected by respiratory and allergic disorders.
| CAS Number | 128312-51-6 |
| Synonyms | 4-[[3-[(1E)-2-(4-Cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxo-Butanoic Acid; Ro 24-5913; |
| Molecular Formula | C23H28N2O3S |
| Purity | ≥95% |
| Target | Leukotriene Receptor |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 2-8°C |
| IUPAC Name | 4-[3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]anilino]-2,2-diethyl-4-oxobutanoic acid |
| InChI | InChI=1S/C23H28N2O3S/c1-3-23(4-2,22(27)28)14-20(26)24-18-10-5-7-16(13-18)11-12-21-25-19(15-29-21)17-8-6-9-17/h5,7,10-13,15,17H,3-4,6,8-9,14H2,1-2H3,(H,24,26)(H,27,28)/b12-11+ |
| InChIKey | BZMKNPGKXJAIDV-VAWYXSNFSA-N |
| SMILES | CCC(CC)(CC(=O)NC1=CC=CC(=C1)C=CC2=NC(=CS2)C3CCC3)C(=O)O |
| Reference | </br>1:Complexation study of cinalukast and montelukast with cyclodextrines. Durán Merás I, Espinosa-Mansilla A, Rodríguez DA.J Pharm Biomed Anal. 2007 Feb 19;43(3):1025-32. Epub 2006 Nov 21. PMID: 17118608 </br>2:Prolonged protection against exercise-induced bronchoconstriction by the leukotriene D4-receptor antagonist cinalukast. Adelroth E, Inman MD, Summers E, Pace D, Modi M, O/’Byrne PM.J Allergy Clin Immunol. 1997 Feb;99(2):210-5. PMID: 9042047 |
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