Cinnabarinic Acid

• CAT Number: R011057
• CAS Number: 606-59-7
• Molecular Formula: C14H8N2O6
• Molecular Weight: 300.22
• Purity: ≥95%
• Synonyms: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic Acid; Cinnabaric Acid
• Target: GluR
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at 2-8°C
• IUPAC Name: 2-amino-3-oxophenoxazine-1,9-dicarboxylic acid
• InChI: InChI=1S/C14H8N2O6/c15-10-6(17)4-8-12(9(10)14(20)21)16-11-5(13(18)19)2-1-3-7(11)22-8/h1-4H,15H2,(H,18,19)(H,20,21)
• InChIKey: FSBKJYLVDRVPTK-UHFFFAOYSA-N
• SMILES: C1=CC(=C2C(=C1)OC3=CC(=O)C(=C(C3=N2)C(=O)O)N)C(=O)O

Cinnabarinic acid（Cat No.:R011057） is an endogenous metabolite produced by the tryptophan kynurenine pathway. It acts as a specific allosteric agonist for the metabotropic glutamate receptor subtype 4 (mGlu4) and selectively interacts with the glutamate-binding pocket residues of mGlu4, with no activity on other mGlu receptor subtypes. Cinnabarinic acid’s ability to induce apoptosis makes it a valuable compound in research related to neuronal cell death and potential therapeutic applications for neurological disorders. Its specific interaction with mGlu4 receptors holds promise for targeted drug development in neurodegenerative diseases.