For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer.<br>IC50 value:<br>Target:<br>In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2].<br>In vivo:<br></p>
| Catalog Number | I003629 |
| CAS Number | 470-37-1 |
| Molecular Formula | C26H34O6 |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | DMSO: 43 mg/mL |
| Storage | Store at -20C |
| InChI | InChI=1S/C26H34O6/c1-14(27)31-22-21(15-8-11-30-20(29)12-15)25(3)10-7-18-19(26(25)23(22)32-26)5-4-16-13-17(28)6-9-24(16,18)2/h8,11-12,16-19,21-23,28H,4-7,9-10,13H2,1-3H3/t16-,17+,18-,19+,21+,22-,23-,24+,25+,26-/m1/s1 |
| InChIKey | BNZAGRNEEMGADQ-CTAZGAKUSA-N |
| SMILES | CC(O[C@@H]([C@@]1([H])O[C@]123)[C@H](C(C=CO4)=CC4=O)[C@]2(C)CC[C@]5([H])[C@]3([H])CC[C@]6([H])C[C@@H](O)CC[C@@]65C)=O |
| Reference | </br>1:Anti-proliferative and pro-apoptotic effects of cinobufagin on human breast cancer MCF-7 cells and its molecular mechanism. Zhu L, Chen Y, Wei C, Yang X, Cheng J, Yang Z, Chen C, Ji Z.Nat Prod Res. 2017 Apr 17:1-5. doi: 10.1080/14786419.2017.1315575. [Epub ahead of print] PMID: 28412840 </br>2:Reversal of P-gp-mediated multidrug resistance in colon cancer by cinobufagin. Yuan Z, Shi X, Qiu Y, Jia T, Yuan X, Zou Y, Liu C, Yu H, Yuan Y, He X, Xu K, Yin P.Oncol Rep. 2017 Mar;37(3):1815-1825. doi: 10.3892/or.2017.5410. Epub 2017 Jan 30. PMID: 28184922 </br>3:Chinese herb cinobufagin-reduced cancer pain is associated with increased peripheral opioids by invaded CD3/4/8 lymphocytes. Chen T, Yuan S, Wan XN, Zhan L, Yu XQ, Zeng JH, Li H, Zhang W, Hu XY, Ye YF, Hu W.Oncotarget. 2017 Feb 14;8(7):11425-11441. doi: 10.18632/oncotarget.14005. PMID: 28002791 Free PMC Article</br>4:Preclinical study of cinobufagin as a promising anti-colorectal cancer agent. Lu XS, Qiao YB, Li Y, Yang B, Chen MB, Xing CG.Oncotarget. 2017 Jan 3;8(1):988-998. doi: 10.18632/oncotarget.13519. PMID: 27894091 Free PMC Article</br>5:Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling. Cao Y, Yu L, Dai G, Zhang S, Zhang Z, Gao T, Guo W.Eur J Pharmacol. 2017 Jan 5;794:77-84. doi: 10.1016/j.ejphar.2016.11.016. Epub 2016 Nov 12. PMID: 27845066 </br>6:Cinobufagin enhances the protective efficacy of formalin-inactivated Salmonella typhimurium vaccine through Th1 immune response. Wu SC, Yi PF, Guo X, Zhang LY, Xu DX, Fu YX, Cui ZQ, Shen HQ, Wei XB, Fu BD.Microb Pathog. 2016 Oct;99:264-270. doi: 10.1016/j.micpath.2016.08.036. Epub 2016 Aug 26. PMID: 27574776 </br>7:Cinobufagin Modulates Human Innate Immune Responses and Triggers Antibacterial Activity. Xie S, Spelmink L, Codemo M, Subramanian K, Pütsep K, Henriques-Normark B, Olliver M.PLoS One. 2016 Aug 16;11(8):e0160734. doi: 10.1371/journal.pone.0160734. eCollection 2016. PMID: 27529866 Free PMC Article</br>8:Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway. Ma K, Zhang C, Huang MY, Li WY, Hu GQ.Oncol Rep. 2016 Jul;36(1):90-8. doi: 10.3892/or.2016.4782. Epub 2016 Apr 28. PMID: 27176794 Free PMC Article</br>9:Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells. Zhang G, Wang C, Sun M, Li J, Wang B, Jin C, Hua P, Song G, Zhang Y, Nguyen LL, Cui R, Liu R, Wang L, Zhang X.Oncotarget. 2016 May 17;7(20):28935-46. doi: 10.18632/oncotarget.7898. PMID: 26959116 Free PMC Article</br>10:Immunomodulatory Effects of Cinobufagin on Murine Lymphocytes and Macrophages. Yu Y, Wang H, Meng X, Hao L, Fu Y, Fang L, Shen D, Yu X, Li J.Evid Based Complement Alternat Med. 2015;2015:835263. doi: 10.1155/2015/835263. Epub 2015 Nov 19. PMID: 26664411 Free PMC Article |
