Cintirorgon

• CAT Number: I020491
• CAS Number: 2055536-64-4
• Molecular Formula: C₂₇H₂₃F₆NO₆S
• Molecular Weight: 603.53
• Purity: ≥95%
• Target: Vitamin D Related/Nuclear Receptor
• IUPAC Name: 3-[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid
• InChI: InChI=1S/C27H23F6NO6S/c1-26(2,24(35)36)13-20-14-34(41(37,38)21-5-3-4-17(11-21)27(31,32)33)22-10-15(6-7-23(22)39-20)16-8-18(28)12-19(9-16)40-25(29)30/h3-12,20,25H,13-14H2,1-2H3,(H,35,36)/t20-/m0/s1
• InChIKey: GULSIMHVQYBADX-FQEVSTJZSA-N
• SMILES: CC(C)(C[C@H]1CN(C2=C(O1)C=CC(=C2)C3=CC(=CC(=C3)F)OC(F)F)S(=O)(=O)C4=CC=CC(=C4)C(F)(F)F)C(=O)O

Cintirorgon (CAT: I020491) is a potent and selective inhibitor of heat shock protein 90 (HSP90), a molecular chaperone involved in the stabilization and activation of numerous client proteins critical for cancer cell growth and survival. By inhibiting HSP90, Cintirorgon promotes the degradation of oncogenic proteins, disrupting key signaling pathways involved in tumor progression, cell proliferation, and angiogenesis. This mechanism makes Cintirorgon a promising candidate in oncology research, particularly for targeting cancers driven by aberrant protein signaling, such as solid tumors and hematological malignancies, offering potential for novel cancer therapies.