cis-8,11,14-Eicosatrienoic Acid

• CAT Number: R054700
• CAS Number: 1783-84-2
• Molecular Formula: C20H34O2
• Molecular Weight: 306.49
• Purity: ≥95%
• Synonyms: (8Z,11Z,14Z)-8,11,14-Eicosatrienoic Acid; (Z,Z,Z)-8,11,14-Eicosatrienoic Acid; 8,11,14-Eicosatrienoic Acid; 8,11,14-all-cis-Eicosatrienoic acid; Bishomo-γ-linolenic Acid; DGLA; Dihomo-γ-linolenic Acid; Ro 12-1989; all-cis-8,11,14-Eicosatrienoic Acid
• Storage: -20°C
• IUPAC Name: (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
• InChI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
• InChIKey: HOBAELRKJCKHQD-QNEBEIHSSA-N
• SMILES: CCCCCC=CCC=CCC=CCCCCCCC(=O)O

Dihomo-<wbr></wbr>γ-<wbr></wbr>Linolenic Acid (DGLA, 20:3), an elongation product of γ-<wbr></wbr>linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-<wbr></wbr>series prostaglandins, including PGE1. In mice, DGLA supplementation in the diet can reduce atopic dermatitis and atherosclerosis.