Cisd2 agonist 1

• CAT Number: I040885
• CAS Number: 2916371-54-3
• Molecular Formula: C14H13FN2O3S
• Molecular Weight: 308.33
• Purity: ≥95%
• Synonyms: methyl 2-amino-5-[(4-fluorophenyl)carbamoyl]-4-methylthiophene-3-carboxylate
• InChI: InChI=1S/C14H13FN2O3S/c1-7-10(14(19)20-2)12(16)21-11(7)13(18)17-9-5-3-8(15)4-6-9/h3-6H,16H2,1-2H3,(H,17,18)
• InChIKey: QRCRHHUPIOWOOO-UHFFFAOYSA-N
• SMILES: CC1=C(SC(=C1C(=O)OC)N)C(=O)NC2=CC=C(C=C2)F

Cisd2 agonist 1 (Compound 4q) is a Cisd2 agonist (EC50: 34 nM). Cisd2 agonist 1 enhances the Cisd2 expression and improves the pathological changes in the fatty livers. Cisd2 agonist 1 has good metabolic stability. Cisd2 agonist 1 can be used for research of NAFLD[1].

Reference

[1]. Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583.
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