Cisd2 agonist 2

• CAT Number: I040884
• CAS Number: 2916371-59-8
• Molecular Formula: C14H14N2O4S
• Molecular Weight: 306.34
• Purity: ≥95%
• Synonyms: methyl 2-amino-5-[(4-hydroxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate
• InChI: InChI=1S/C14H14N2O4S/c1-7-10(14(19)20-2)12(15)21-11(7)13(18)16-8-3-5-9(17)6-4-8/h3-6,17H,15H2,1-2H3,(H,16,18)
• InChIKey: RUKNSHPYDAPFMK-UHFFFAOYSA-N
• SMILES: CC1=C(SC(=C1C(=O)OC)N)C(=O)NC2=CC=C(C=C2)O

Cisd2 agonist 2 (compound 6) is an orally active Cisd2 activator (EC50=191 nM), while the Cisd2 levels is correlated with nonalcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant toxicity in vivo in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout)[1].

Reference

[1]. Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583.
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