CJOC42

• CAT Number: I024843
• CAS Number: 2171519-89-2
• Molecular Formula: C20H21N3O5S
• Molecular Weight: 415.46
• Purity: 98%
• Synonyms: CJOC42; CJOC-42; CJOC 42
• Target: MDM-2/p53
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Methyl 4-(4-(3-(tosyloxy)propyl)-1H-1,2,3-triazol-1-yl)benzoate
• InChI: InChI=1S/C20H21N3O5S/c1-15-5-11-19(12-6-15)29(25,26)28-13-3-4-17-14-23(22-21-17)18-9-7-16(8-10-18)20(24)27-2/h5-12,14H,3-4,13H2,1-2H3
• InChIKey: VYUDJPGSULLWAS-UHFFFAOYSA-N
• SMILES: O=C(OC)C1=CC=C(N2N=NC(CCCOS(=O)(C3=CC=C(C)C=C3)=O)=C2)C=C1

CJOC42(CAT: I024843) is a potent and selective inhibitor of gankyrin, an ankyrin-repeat oncoprotein overexpressed in various cancers. By binding to gankyrin in a dose-dependent manner, CJOC42 prevents the degradation of p53 protein levels typically associated with high gankyrin activity. This restoration of p53 functionality enhances p53-dependent transcription and sensitizes cancer cells to DNA damage. CJOC42 is a valuable tool for oncology research, particularly in studying gankyrin’s role in tumorigenesis and developing therapies that leverage p53 reactivation to combat cancer progression. Its specificity and efficacy make it a promising candidate for preclinical studies targeting gankyrin-driven malignancies.