CK 1827452-d8

• CAT Number: R023879
• CAS Number: NA
• Molecular Formula: C₂₀H₁₆D₈FN₅O₃
• Molecular Weight: 409.48
• Purity: ≥95%
• Synonyms: Methyl 4-[[2-Fluoro-3-[N’-(6-methylpyridin-3-yl-d8)ureido]phenyl]methyl]piperazine-1-carboxylate; 4-[[2-Fluoro-3-[[[(6-methyl-3-pyridinyl-d8)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic Acid Methyl Ester; Omecamtiv Mecarbil
• Storage: -20°C
• IUPAC Name: methyl 2,2,3,3,5,5,6,6-octadeuterio-4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate
• InChI: InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)/i8D2,9D2,10D2,11D2
• InChIKey: RFUBTTPMWSKEIW-JNJBWJDISA-N
• SMILES: [2H]C1(C(N(C(C(N1CC2=C(C(=CC=C2)NC(=O)NC3=CN=C(C=C3)C)F)([2H])[2H])([2H])[2H])C(=O)OC)([2H])[2H])[2H]

CK 1827452-d8 is a deuterated analog of CK 1827452, a compound known for its potential in treating heart failure by enhancing cardiac contractility. This version features eight deuterium atoms, making it highly valuable in pharmacological research, particularly in the study of the compound’s pharmacokinetics, metabolism, and drug interactions. The deuterium labeling enhances the precision of mass spectrometric analyses, allowing researchers to accurately track and quantify CK 1827452 in biological systems. CK 1827452-d8 is essential for investigating the metabolic pathways, bioavailability, and therapeutic effects of this cardiac myosin activator. Its high purity and stability ensure reliable and consistent results in advanced cardiovascular research, contributing to the development of effective treatments for heart failure and related conditions.