CK-636

• CAT Number: I003566
• CAS Number: 442632-72-6
• Molecular Formula: C16H16N2OS
• Molecular Weight: 284.4
• Purity: ≥95%
• Synonyms: N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
• Target: Arp2/3 Complex
• Solubility: DMSO: ≥ 49 mg/mL
• Storage: Store at -20 C
• IC50: 4/24/32 uM (Human/fission yeast/bovine Arp2/3) [1]
• InChI: InChI=1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
• InChIKey: ACAKNPKRLPMONU-UHFFFAOYSA-N
• SMILES: O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3

CK-636 (CAT: I003566), also known as CK-0944636, is a small molecule inhibitor of the Arp2/3 complex. It functions by inhibiting actin polymerization, which is a critical process for cell motility and cytoskeletal dynamics. By targeting the Arp2/3 complex, CK-636 disrupts the nucleation of new actin filaments, leading to the inhibition of actin polymerization. This inhibition can have effects on cellular processes that rely on actin dynamics, such as cell migration and morphogenesis.

Reference

[1]. Nolen BJ, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4.