CK-666

• CAT Number: I005884
• CAS Number: 442633-00-3
• Molecular Formula: C18H17FN2O
• Molecular Weight: 296.35
• Purity: ≥95%
• Synonyms: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-​yl)ethyl]benzamide
• Target: Anti-infection
• Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
• Storage: Store at -20°C
• IUPAC Name: 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
• InChI: InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
• InChIKey: UXRKUKRXVWJFER-UHFFFAOYSA-N
• SMILES: CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F

CK-666 (CAT: I005884) is a small molecule inhibitor that specifically targets the actin-related protein 2/3 (Arp2/3) complex. The Arp2/3 complex plays a crucial role in the regulation of actin polymerization, which is essential for various cellular processes, including cell migration, shape changes, and cellular protrusions. CK-666 binds to the Arp2/3 complex, inhibiting its nucleation activity and preventing the formation of branched actin networks. By disrupting actin dynamics, CK-666 impairs the ability of cells to undergo cytoskeletal rearrangements necessary for processes like cell motility and invasion. CK-666 is commonly used as a research tool to investigate the functional significance of the Arp2/3 complex and its involvement in cellular processes and diseases related to actin cytoskeleton dynamics.