For research use only. Not for therapeutic Use.
CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with an IC50 values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively[1].
| Catalog Number | I040911 |
| CAS Number | 1383376-92-8 |
| Synonyms | 4-[3-(4-fluorophenyl)-1-methylpyrazol-4-yl]-7H-furo[3,4-b]pyridin-5-one |
| Molecular Formula | C17H12FN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H12FN3O2/c1-21-8-13(16(20-21)10-2-4-11(18)5-3-10)12-6-7-19-14-9-23-17(22)15(12)14/h2-8H,9H2,1H3 |
| InChIKey | XISSYJGQGSMWHO-UHFFFAOYSA-N |
| SMILES | CN1C=C(C(=N1)C2=CC=C(C=C2)F)C3=C4C(=NC=C3)COC4=O |
| Reference | [1]. Joris De Maeyer, et al. Casein kinase 1 inhibitors for use in the treatment of diseases related to dux4 expression such as muscular dystrophy and cancer. WO2020249717A1. |
